Key result
The Vicenza score had poor diagnostic utility for identifying bleeding disorders among 104 children (8 definite type 1 VWD, 23 low VWF, 13 PFD), with simpler criteria offering comparable NPV.
Why the study?
Does the Vicenza score accurately predict type 1 von Willebrand's disease and platelet function defects in children referred for bleeding disorders?
Population
104 children referred to a paediatric haematology clinic for evaluation of a bleeding disorder
Comparison
Vicenza score vs Simpler qualitative criteria
Design
Cohort
Authors
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Caution against routine Vicenza score use in children; leaves open whether simpler criteria suffice pending prospective validation.
Cohort (n=104)
Does the Vicenza score accurately predict type 1 von Willebrand's disease and platelet function defects in children referred for bleeding disorders?
The Vicenza score has limited predictive value in pediatric tertiary care settings for diagnosing bleeding disorders, and simpler qualitative criteria are similarly predictive for excluding definite type 1 VWD.
Marcus et al. (2010) conducted a cohort in Bleeding disorders (type 1 VWD, low VWF, PFD) (n=104). Vicenza score vs. Qualitative criteria (>2 bleeding symptoms) was evaluated on Identifying type 1 VWD, low VWF and platelet function defects (PFD). The Vicenza score had poor diagnostic utility for identifying bleeding disorders among 104 children (8 definite type 1 VWD, 23 low VWF, 13 PFD), with simpler criteria offering comparable NPV.
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