Key result
Statin therapy demonstrated no statistically significant differences in overall psychological wellbeing compared to placebo (SMD -0.08, 95% CI -0.29 to 0.12; P = 0.42).
Why the study?
Do statins impact psychological wellbeing in individuals with or without hypercholesterolemia?
Meta-Analysis (n=2,105)
Do statins impact psychological wellbeing in individuals with or without hypercholesterolemia?
Standardized Mean Difference: -0.08 (95% CI -0.29–0.12)
p-value: p=0.42
This meta-analysis refutes concerns that statins negatively impact psychological wellbeing and suggests potential mood-related benefits.
Reassures on statin safety for psychological wellbeing; confirms neutral effect versus placebo in Level 1 evidence.
BACKGROUND: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia. METHODS: Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model. RESULTS: The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24). CONCLUSIONS: Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.
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O’Neil et al. (2012) conducted a meta-analysis in Hypercholesterolemia or healthy (n=2,105). Statins vs. Placebo was evaluated on Psychological wellbeing (depression and mood) (SMD -0.08, 95% CI -0.29 to 0.12, p=0.42). Statin therapy demonstrated no statistically significant differences in overall psychological wellbeing compared to placebo (SMD -0.08, 95% CI -0.29 to 0.12; P = 0.42).
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