Key result
Lipophilic statins link to improved psychological well-being and reduced anxiety and depressive symptoms.
Why the study?
Epidemiological and clinical studies have suggested that powerful cholesterol lowering by statins may adversely affect mood and psychological well-being, prompting focused scientific interest in statins' effects on mental health.
Does statin therapy have adverse effects on mental health?
Does statin therapy have adverse effects on mental health?
This review examines the literature regarding the potential adverse effects of statin therapy and LDL cholesterol lowering on mental health.
Answers are grounded in this paper and cite their sources.
Statins may improve rather than impair mood parameters; leaves open confirmation of antidepressant effects in prospective trials.
Background Epidemiological and clinical studies have suggested that powerful cholesterol lowering may have adverse effects on mood and psychological well-being. Reports in the early 1990s showed that LDL cholesterol lowering might have an undesirable impact on mental health (possible increase of violence, accidents and suicide). As a result, the scientific interest is strongly focused on the effects of statins therapy on mental status (i.e. irritability, depressive symptoms, and anxiety). The aim of our study is to review the literature involving statins and mental health and to analyze it by time.
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Pazarlis et al. (2006) conducted a review in Mental health and cholesterol lowering. Statins was evaluated on Psychological well-being (depressive symptoms, anxiety, hostility). Statins, particularly lipophilic ones, appear to improve psychological well-being and reduce depressive symptoms, anxiety, and hostility, possibly through an immunomodulatory mechanism.
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