Key result
Statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia.
Why the study?
Statins have anti-inflammatory and anti-oxidant effects thought to be responsible for potential effects on various psychiatric disorders, motivating a comprehensive review of their psychiatric effects, adverse effects, and drug interactions.
Do statins improve symptoms or reduce the risk of psychiatric disorders such as depression, schizophrenia, and dementia?
Do statins improve symptoms or reduce the risk of psychiatric disorders such as depression, schizophrenia, and dementia?
Statins may offer a novel adjunctive therapeutic opportunity for psychiatric disorders like depression and schizophrenia due to their anti-inflammatory properties, though larger, long-term trials are needed.
Should not yet change psychiatric prescribing; leaves open adjunctive statin efficacy pending RCTs.
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders.
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Kim et al. (2019) conducted a review in Psychiatric disorders (depression, schizophrenia, dementia). Statins was evaluated. Statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia.
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