Why the study?
Does cibenzoline provide effective and safe long-term antiarrhythmic therapy in patients with chronic ventricular arrhythmias?
Population
19 patients with chronic ventricular arrhythmias (including 6 with preexisting left ventricular dysfunction)
Comparison
Cibenzoline vs Placebo
Design
Single-blind
Follow-up
long-term (exact duration not specified)
Authors
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Supports periodic efficacy reassessment on cibenzoline; leaves open durability of response in chronic ventricular arrhythmias.
Does cibenzoline provide effective and safe long-term antiarrhythmic therapy in patients with chronic ventricular arrhythmias?
Cibenzoline is effective for short-term suppression of chronic ventricular arrhythmias and appears safe in compensated LV dysfunction, but its long-term efficacy is frequently lost, requiring periodic reassessment.
Mohiuddin et al. (1987) studied this question.
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