Key result
Cifenline significantly suppresses premature ventricular complexes and pairs compared with placebo.
Why the study?
The efficacy and safety of cifenline, a new antiarrhythmic agent, in treating patients with frequent ventricular premature complexes was studied.
Does cifenline reduce ventricular premature complexes in patients with >700 VPCs/24 h?
RCT (n=46)
Double-blind
Does cifenline reduce ventricular premature complexes in patients with >700 VPCs/24 h?
p-value: p=<0.0001
Cifenline is effective in the short-term suppression of frequent ventricular premature complexes, though it is associated with a small increase in QRS duration and some adverse effects.
Cifenline suppresses frequent VPCs more than placebo; extends evidence for class Ia agents in ventricular ectopy management.
To study the efficacy and safety of cifenline (cibenzoline), a new antiarrhythmic agent, we enrolled 46 patients with greater than 700 premature ventricular complexes (VPCs)/24 h in an ambulatory electrocardiography study. During an open-label titration phase, 25 patients showed greater than 75% VPC suppression while receiving 130 mg (15 patients) or 160 mg (10 patients) cifenline twice daily. During a double-blind placebo-controlled phase in 23 of these patients, cifenline was more effective than placebo in controlling VPCs (p less than 0.0001) and VPC pairs (p less than 0.025). A small (0.01 s) increase in QRS duration was observed (p less than 0.05) during cifenline treatment. Adverse experiences included gastrointestinal complaints and dizziness as well as two instances of hypotension and one instance of symptomatic ventricular tachycardia. Cifenline appears to be effective and well tolerated in the treatment of VPCs.
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Davis et al. (1989) conducted an RCT in Ventricular Premature Complexes (n=46). Cifenline vs. Placebo was evaluated on Controlling VPCs (p=<0.0001). Cifenline was more effective than placebo in controlling premature ventricular complexes (P<0.0001) and VPC pairs (P<0.025).
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