Key result
SERCA1a overexpression significantly attenuated hydroxyl radical-induced contractile dysfunction compared to wild-type mice (developed force decreased to 51% vs 11%, P<0.05).
Population
Right ventricular papillary muscles from wild-type, SERCA1a-overexpressing, and SERCA2a heterogeneous…
Comparison
SERCA1a overexpression (transgenic mice) vs Wild-type mice and SERCA2a heterogeneous…
Design
Preclinical
Follow-up
45 minutes post-exposure
Authors
Loading...
Does not support clinical use; hypothesis-generating for SERCA-targeted protection in oxidative cardiac injury.
p-value: p=<0.05
SERCA overexpression reduces hydroxyl radical-induced contractile dysfunction in murine myocardium, highlighting the protective role of enhanced SR Ca(2+)-ATPase activity against oxidative injury.
Hiranandani et al. (2006) studied Hydroxyl radical injury in murine myocardium. SERCA1a overexpression vs. Wild-type (WT) and SERCA2a heterogeneous knockout (HET) mice was evaluated on Contractile dysfunction (diastolic force and developed force) (p=<0.05). SERCA1a overexpression significantly attenuated hydroxyl radical-induced contractile dysfunction compared to wild-type mice (developed force decreased to 51% vs 11%, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: