Key result
In female ApoE-Ko mice, the combination of ovariectomy and a high-fat diet significantly increased final body weight, adipose tissue, and resting heart rate while decreasing baroreflex sensitivity compared to controls.
Why the study?
Postmenopausal women tend to have greater adiposity that increases cardiovascular risk and atherosclerosis, prompting evaluation of the combined effects of ovarian deprivation and high-fat diet on metabolic, hemodynamic, and autonomic outcomes in an experimental atherosclerosis model.
Does ovariectomy combined with a high-fat diet induce autonomic dysfunction, cardiac remodeling, and metabolic changes in female ApoE-Ko mice?
Does ovariectomy combined with a high-fat diet induce autonomic dysfunction, cardiac remodeling, and metabolic changes in female ApoE-Ko mice?
Absolute Event Rate: 36.86% vs 27.24%
p-value: p=<0.0001
In an ApoE-Ko mouse model, the combination of ovarian deprivation and a high-fat diet exacerbates metabolic dysfunction, cardiac remodeling, and autonomic impairment.
Preclinical data suggest menopause-diet synergy affects autonomic control in atherosclerosis models; leaves open human translation.
Atherosclerosis is a chronic inflammatory disease characterized by the formation of atheroma plaque in the arterial wall, process that causes long-term obstruction of the arteries. Postmenopausal women tend to have greater body adiposity, factor that corroborate to increased risk of cardiovascular events and development of atherosclerosis. Therefore, the aim of this study was to evaluate the association of experimental model of atherosclerosis with ovarian deprivation and consumption of high-fat diet in metabolic, hemodynamic, and autonomic outcomes. 21 female ApoE-Ko were divided into 3 groups (n = 7 in each): control treated with normolipidic diet (C); ovariectomized treated with normolipidic diet (Ovx); ovariectomized treated with high-fat diet (OvxHF). Hemodynamic parameters, baroreflex sensitivity and cardiovascular autonomic modulation were evaluated. Values (mean ± standard error of mean) were analyzed by One-way ANOVA, followed by Tukey's post hoc (p<0.05). The OvxHF showed increase in final body weight, adipose tissue, tachycardia at rest, in addition, there was a decrease in muscle mass, functional capacity, baroreflex sensitivity associated with less cardiac autonomic modulation. These findings provide evidence about the risk by the loss of ovarian hormones with food consumption and demonstrate the importance of adhering to prevention and treatment strategies.
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Izaías et al. (2021) studied Atherosclerosis (ApoE-Ko model) (n=21). Ovariectomy and high-fat diet vs. Control (normolipidic diet) and Ovariectomy (normolipidic diet) was evaluated on Final body weight (grams) (p=<0.0001). In female ApoE-Ko mice, the combination of ovariectomy and a high-fat diet significantly increased final body weight, adipose tissue, and resting heart rate while decreasing baroreflex sensitivity compared to controls.
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