Population
In vitro models and cells expressing influenza virus nucleoprotein (NP)
Comparison
Mutation of NP to disrupt F-actin binding vs Wild-type NP or NP with intact F-actin binding
Design
Preclinical
Authors
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NP-F-actin binding may retain influenza NP cytoplasmically; leaves open whether this interaction can be targeted to alter viral trafficking.
The interaction of influenza virus nucleoprotein with F-actin causes its cytoplasmic retention, overriding nuclear localization signals.
Digard et al. (1999) studied this question.
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