Population
Influenza A virus NS1 protein in uninfected transfected cells and infected cells
Comparison
Substitution of alanine residues in the adjacent… vs Wild-type NS1 protein; uninfected cells
Design
Preclinical
Authors
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Hypothesis-generating for NS1-targeted antivirals; leaves open relevance to human infection and clinical translation.
The influenza A virus NS1 protein contains a latent nuclear export signal regulated by an adjacent inhibitory sequence, which is unmasked during viral infection.
Li et al. (1998) studied this question.
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