Population
Cells infected with influenza virus or adenovirus vector containing NS1 gene
Comparison
Adenovirus vector containing NS1 gene vs Influenza virus-infected cells
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether NS1 mRNA transport regulates splicing in human viral infections.
The study demonstrates that nucleocytoplasmic transport of unspliced NS1 mRNA plays an important role in regulating the extent of its splicing.
Alonso-Caplen et al. (1991) studied this question.
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