February 1, 1991Molecular and Cellular Biology

Regulation of the Extent of Splicing of Influenza Virus NS1 mRNA: Role of the Rates of Splicing and of the Nucleocytoplasmic Transport of NS1 mRNA

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Population

Influenza virus-infected cells and cells infected with an adenovirus vector containing the NS1 gene

Comparison

Insertion of NS1 gene into an adenovirus vector… vs Influenza virus-infected cells

Design

Preclinical

Authors

FAFirelli V. Alonso-CaplenRutgers, The State University of New Jersey RKRobert M. KrugThe University of Texas at Austin

Discussion

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Implication

Nuclear retention regulates NS1 splicing extent; leaves open whether this mechanism can be targeted in influenza.

Structured PICO

Population

Influenza virus-infected cells and cells infected with an adenovirus vector containing the NS1 gene

Intervention

Insertion of NS1 gene into an adenovirus vector; mutation of 3' splice site of NS1 mRNA

Comparator

Influenza virus-infected cells

Outcome

Rate and extent of splicing of NS1 mRNA and nucleocytoplasmic transportsurrogate

The extent of splicing of influenza virus NS1 mRNA is regulated by the nucleocytoplasmic transport of unspliced NS1 mRNA rather than by trans factors controlling the rate of splicing.

Cite This Study

Alonso-Caplen et al. (1991) studied this question.

synapsesocial.com/papers/6a8aa06fd513dfc69d721e1e https://doi.org/10.1128/mcb.11.2.1092-1098.1991

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Regulation of the Extent of Splicing of Influenza Virus NS1 mRNA: Role of the Rates of Splicing and of the Nucleocytoplasmic Transport of NS1 mRNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of the Extent of Splicing of Influenza Virus NS1 mRNA: Role of the Rates of Splicing and of the Nucleocytoplasmic Transport of NS1 mRNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider