Key result
Markers of oxidative stress and inflammatory response were significantly increased (P<0.001) in elderly patients with coexistent severe carotid and multivessel coronary artery stenosis.
Why the study?
Oxidative stress and inflammatory response are primary pathogenic pathways in atherosclerotic stenosis, but their roles in coexistent right carotid artery severe stenosis and severe multivessel coronary artery stenosis in elderly patients needed evaluation.
Are oxidative stress and inflammatory biomarkers elevated in elderly patients with coexistent severe multivessel coronary artery stenosis and right carotid artery severe stenosis?
Observational
Are oxidative stress and inflammatory biomarkers elevated in elderly patients with coexistent severe multivessel coronary artery stenosis and right carotid artery severe stenosis?
p-value: p=<0.001
Oxidative stress and inflammatory biomarkers are significantly elevated in elderly patients with coexistent severe multivessel coronary and right carotid artery stenosis, suggesting a potential role in monitoring disease severity.
Points to oxidative-inflammatory pathways in elderly with coexistent stenoses; hypothesis-generating for targeted therapies without current practice implications.
Oxidative stress and inflammatory response are the main pathogenic pathways in atherosclerosis stenosis. This study is aimed at evaluating the roles of oxidative stress and inflammatory response in coexistent right carotid artery severe stenosis and severe multivessel coronary artery stenosis in elderly patients. Circulating levels of total oxidant status (TOS), lipid hydroperoxide (LHP), 8‐isoprostane (8‐IP), malondialdehyde (MDA), monocyte chemotactic protein‐4 (MCP‐4), amyloid A (AA), high‐sensitivity C‐reactive protein (hs‐CRP), and tumor necrosis factor‐ α (TNF‐ α ) were measured by standardised laboratory test methods. Markers of oxidative stress and inflammatory response: levels of TOS, LHP, 8‐IP, MDA, MCP‐4, AA, hs‐CRP, and TNF‐ α , were increased ( P < 0.001) in elderly patient. These results suggested that oxidative stress and inflammatory response may be involved in carotid artery severe stenosis and severe multivessel coronary artery stenosis and measuring oxidative stress and inflammation biomarkers may also be a promising step in the development of an effective method for monitoring the severity of right carotid artery stenosis and multivessel coronary artery stenosis in elderly patients.
No takes yet. Share an insight, caveat, or question.
Li et al. (2021) conducted an observational in Coexistent right carotid artery severe stenosis and severe multivessel coronary artery stenosis. Coexistent right carotid artery severe stenosis and severe multivessel coronary artery stenosis was evaluated on Levels of oxidative stress and inflammatory markers (TOS, LHP, 8-IP, MDA, MCP-4, AA, hs-CRP, and TNF-α) (p=<0.001). Markers of oxidative stress and inflammatory response were significantly increased (P<0.001) in elderly patients with coexistent severe carotid and multivessel coronary artery stenosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: