Key result
Elevated levels of oxidized low-density lipoprotein (oxLDL) were significantly associated with an increased risk of high carotid intima-media thickness (OR 1.65) in patients with chronic kidney disease.
Why the study?
Atherosclerosis is accelerated in CKD and oxidative stress is considered a pro-atherogenic factor, but the relationship between oxidative stress markers and carotid atherosclerosis progression in CKD required determination.
Are oxidative stress markers associated with the progression of carotid atherosclerosis in patients with chronic kidney disease?
Cohort (n=202)
No
Are oxidative stress markers associated with the progression of carotid atherosclerosis in patients with chronic kidney disease?
Odds Ratio: 1.65 (95% CI 1.3–2.1)
p-value: p=0.0001
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Oxidative stress markers may associate with carotid atherosclerosis progression in CKD; leaves open causal role and need for interventional trials.
Azouaou et al. (2020) conducted a cohort in Chronic kidney disease and carotid atherosclerosis (n=202). Oxidative stress markers (specifically oxLDL) vs. Lower levels of oxidative stress markers / Healthy controls was evaluated on High carotid intima-media diameter (IMD > 1 mm) (OR 1.65, 95% CI 1.30-2.10, p=0.0001). Elevated levels of oxidized low-density lipoprotein (oxLDL) were significantly associated with an increased risk of high carotid intima-media thickness (OR 1.65) in patients with chronic kidney disease.
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