Key result
In patients on regular hemodialysis, plasma TBARS concentration showed a highly significant positive correlation with carotid intima-media thickness (r=0.550, p=0.0001).
Why the study?
Oxidative stress is a significant risk factor for accelerated atherosclerosis in hemodialysis patients, prompting investigation into its correlation with carotid artery intima-media thickness and other clinical parameters.
Cross-Sectional (n=125)
No
Effect estimate: r=0.550
p-value: p=0.0001
In hemodialysis patients, increased oxidative stress markers (higher TBARS and H2O2, lower SOD) are significantly correlated with increased carotid artery intima-media thickness, suggesting oxidative stress is a key risk factor for accelerated atherosclerosis in this population.
Oxidative stress markers associate with carotid IMT in hemodialysis; hypothesis-generating for antioxidant interventions pending prospective trials.
Oxidative stress represents a significant risk factor for the accelerated development of atherosclerosis in a population of patients on regular hemodialysis. Oxidative stress induced by hemodialysis can be triggered with both the bioincompatibility of dialysis membrane and increased endotoxin concentration in a hemodialysis solution. The aim of this study was to investigate the correlation between the parameters of oxidative stress, microinflammation, nutrition, secondary hyperparathyroidism and carotid artery intima-media thickness in patients on regular hemodialysis.One hundred and twenty five patients treated with standard hemodialysis and on-line hemodiafiltration with "high-flux" polysulfone dialysis membrane were examined. The following parameters of oxidative stress were measured : index of lipid peroxidation - measured as TBARS, nitric oxide in the form of nitrite - NO 2 -, super oxide anion radical - O 2 - and hydrogen peroxide - H 2 O 2 , catalase, superoxide dismutase (SOD) and reduced glutathione activity. For statistical analysis of results, the following tests were used: the Kolmogorov-Smirnov test, the Spirman test and the Pearson correlation test. Oxidative stress affects atherosclerosis of the carotid arteries in patients treated with regular hemodialysis and online hemodiafiltration. There is a statistically significant positive correlation between H 2 O 2 concentration and the thickness of the carotid arteries` intima-media. High statistically significant positive correlation was found between TBARS concentration and carotid arteries intima-media thickness, while a high statistically significant negative correlation was found between SOD activity and a carotid artery intima-media thickness. There is a statistically significant negative correlation between the serum albumin and prealbumin concentration and a carotid artery intima-media thickness. Oxidative stress may be a significant risk factor for the carotid artery atherosclerosis development in patients treated with regular hemodialysis.
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Antić et al. (2019) conducted a cross-sectional in End-stage renal disease on regular hemodialysis (n=125). Oxidative stress (TBARS, H2O2, SOD) was evaluated on Correlation between oxidative stress parameters and carotid artery intima-media thickness (IMT) (r=0.550, p=0.0001). In patients on regular hemodialysis, plasma TBARS concentration showed a highly significant positive correlation with carotid intima-media thickness (r=0.550, p=0.0001).
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