Key result
Progressive stages of chronic kidney disease were associated with a highly significant progressive decrease in nitric oxide and superoxide dismutase levels compared with healthy controls.
Observational (n=72)
Progressive decline in kidney function is associated with decreased antioxidant levels (NO and SOD) and worsening lipid profiles, which may contribute to the high cardiovascular risk in CKD patients.
ObjectiveThe aim of this work was to evaluate nitric oxide (NO) and superoxide dismutase (SOD) as parameters of oxidative stress in different stages of chronic kidney disease (CKD) and their correlation with the lipid profile.BackgroundCKD is a debilitating disease that leads to many complications, the most common being cardiovascular. Hence, this study was carried out to evaluate the oxidative stress that predisposes to cardiovascular diseases in these patients.MethodsThis study included 60 patients with CKD. In addition, 12 apparently healthy age-matched and sex-matched individuals were included as a control group. Patients were classified into five groups according to estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI formula. We estimated serum creatinine, urea, lipid profile [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)], serum NO, and SOD levels.ResultsThere was a progressive increase in the mean value of TC, TG, and LDL-c from group I to group V, whereas HDL-c decreased progressively from group I to group V. There was a highly significant progressive decrease in the mean value of NO and SOD from group I to group V when compared with the controls and on comparison of groups with each other. There was no significant correlation between NO and SOD with other parameters in group I, group II, and group III. However, there was a significant positive correlation between NO and SOD with eGFR, HDL-c and a significant negative correlation between NO and SOD with urea, creatinine, TC, TG, and LDL-c in group IV and group V.ConclusionThis study suggests that the progressive decline in kidney function could lead to decreased antioxidants levels along with disturbance in the lipid profile.
No takes yet. Share an insight, caveat, or question.
El-Gamacy et al. (2013) conducted an observational in Chronic kidney disease (n=72). Chronic kidney disease stages vs. Healthy controls was evaluated on Serum nitric oxide (NO) and superoxide dismutase (SOD) levels. Progressive stages of chronic kidney disease were associated with a highly significant progressive decrease in nitric oxide and superoxide dismutase levels compared with healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: