What does this research mean for the field?

Chronic kidney disease patients, both with and without hypertension, exhibit significantly decreased antioxidant enzyme levels and elevated malondialdehyde, indicating increased oxidative stress. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 30, 2014International Journal of Biomedical and Advance ResearchOpen Access

CKD links to decreased antioxidant enzymes and increased malondialdehyde versus healthy controls regardless of hypertension.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Chronic Kidney Disease with and without hypertension (n=241). Intervention: Chronic Kidney Disease with and without hypertension vs. Healthy controls. Primary outcome: Levels of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, and Malondialdehyde (MDA) (p=0.001).

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Why the study?

Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?

Population

241 subjects including 78 CKD patients with hypertension, 72 CKD patients without hypertension, and 91…

Design

Case-control

Key result

CKD patients with and without hypertension had significantly decreased levels of antioxidant enzymes and increased malondialdehyde compared to healthy controls (p=0.001).

Authors

KKKamal Kachhawa MVMeena Varma ASAnkita Sahu

Discussion

Member takes

Overview

Oxidative stress markers may warrant monitoring in hypertensive CKD; leaves open whether antioxidants alter progression.

Study Design

Type

Observational (n=241)

Structured PICO

Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?

Population

241 subjects comprising 78 CKD patients with hypertension, 72 CKD patients without hypertension, and 91 healthy controls.

Comparator

Healthy controls and CKD patients without hypertension

Outcome

Levels of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA), serum urea, serum creatinine and serum uric acidsurrogate

Main Result

p-value: p=0.001

Hypertensive patients with chronic kidney disease exhibit significantly reduced antioxidant enzyme activities and increased oxidative stress markers.

Cite This Study

Kachhawa et al. (2014) conducted an observational in Chronic Kidney Disease with and without hypertension (n=241). Chronic Kidney Disease with and without hypertension vs. Healthy controls was evaluated on Levels of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, and Malondialdehyde (MDA) (p=0.001). CKD patients with and without hypertension had significantly decreased levels of antioxidant enzymes and increased malondialdehyde compared to healthy controls (p=0.001).

synapsesocial.com/papers/6aa8e072bc25ca06ee299864 https://doi.org/10.7439/ijbar.v5i10.833

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October 30, 2014International Journal of Biomedical and Advance ResearchOpen Access

CKD links to decreased antioxidant enzymes and increased malondialdehyde versus healthy controls regardless of hypertension.

View Full Paper

Ask AI

Bookmark

Why the study?

Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?

Population

241 subjects including 78 CKD patients with hypertension, 72 CKD patients without hypertension, and 91…

Design

Case-control

Key result

CKD patients with and without hypertension had significantly decreased levels of antioxidant enzymes and increased malondialdehyde compared to healthy controls (p=0.001).

Authors

KKKamal Kachhawa MVMeena Varma ASAnkita Sahu

Discussion

Member takes

Overview

Oxidative stress markers may warrant monitoring in hypertensive CKD; leaves open whether antioxidants alter progression.

Study Design

Type

Observational (n=241)

Structured PICO

Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?

Population

241 subjects comprising 78 CKD patients with hypertension, 72 CKD patients without hypertension, and 91 healthy controls.

Comparator

Healthy controls and CKD patients without hypertension

Outcome

Levels of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA), serum urea, serum creatinine and serum uric acidsurrogate

Main Result

p-value: p=0.001

Hypertensive patients with chronic kidney disease exhibit significantly reduced antioxidant enzyme activities and increased oxidative stress markers.

Cite This Study

synapsesocial.com/papers/6aa8e072bc25ca06ee299864 https://doi.org/10.7439/ijbar.v5i10.833

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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