Key result
CKD patients with and without hypertension had decreased levels of antioxidant enzymes and increased malondialdehyde compared to healthy controls.
Why the study?
Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?
Observational (n=241)
Are oxidative stress and antioxidant enzyme levels altered in hypertensive chronic kidney disease patients compared to normotensive CKD patients and healthy controls?
Hypertensive patients with chronic kidney disease exhibit significantly reduced antioxidant enzyme activities and increased oxidative stress markers.
Answers are grounded in this paper and cite their sources.
Oxidative stress markers may warrant monitoring in hypertensive CKD; leaves open whether antioxidants alter progression.
Background: Hypertension is one of the most important factor associated with the progression of both diabetic and non diabetic CKD (chronic kidney disease). In the general population showed that hypertension is a strong independent risk factor for ESRD (end stage renal disease). Methods : Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA), serum urea, serum creatinine and serum uric acid were assayed in 241 subjects In which 78 CKD patients with hypertension, 72 CKD patients without hypertension and 91 healthy controls. Results: In our study, we found statistical significantly significant decreased level (p 0.001) of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase and significant increase level (p 0.001) of malondialdehyde (MDA) in CKD with and without hypertension and also found deranged renal functions. Conclusion: The reduced activities of antioxidant enzymes status and increased production of malondialdehyde in the hypertensive patients confirms the presence of oxidative stress The data suggest that alteration in antioxidant status and MDA in hypertensive CKD patients that binds support to role of oxidative stress in hypertensive patient.
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Kachhawa et al. (2014) conducted an observational in Chronic Kidney Disease with and without hypertension (n=241). Chronic Kidney Disease with and without hypertension vs. Healthy controls was evaluated on Levels of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase, and Malondialdehyde (MDA) (p=0.001). CKD patients with and without hypertension had decreased levels of antioxidant enzymes and increased malondialdehyde compared to healthy controls.
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