Why the study?
Activation of the renin-angiotensin system in hypertension was believed to drive endothelial dysfunction, micro-inflammation, and reactive oxygen species generation, motivating an evaluation of blood pressure interactions with cardiovascular risk factors in CKD.
Is high blood pressure associated with elevated oxidative stress, inflammatory markers, and albuminuria in patients with chronic kidney disease?
Population
71 patients with CKD across three hospitals in Surabaya, Indonesia
Comparison
Participants grouped by systolic and diastolic blood pressure levels
Design
Observational cross-sectional study
Key result
High systolic blood pressure in patients with chronic kidney disease was significantly associated with higher urine albumin-to-creatinine ratio (median 1789 vs 164, p<0.001) and increased inflammation.
Authors
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High BP associated with oxidative stress, inflammation, and albuminuria in CKD; leaves open whether tighter control mitigates these markers in prospective studies.
Cross-Sectional (n=71)
Yes
Is high blood pressure associated with elevated oxidative stress, inflammatory markers, and albuminuria in patients with chronic kidney disease?
Absolute Event Rate: 1789% vs 164%
p-value: p=<0.001
In patients with CKD, high blood pressure is significantly associated with increased markers of inflammation, oxidative stress, and albuminuria.
Thaha et al. (2019) conducted a cross-sectional in Chronic Kidney Disease (n=71). High systolic blood pressure (>139 mmHg) vs. Normal systolic blood pressure was evaluated on Urine Albumin-to-Creatinine Ratio (ACR) (p=<0.001). High systolic blood pressure in patients with chronic kidney disease was significantly associated with higher urine albumin-to-creatinine ratio (median 1789 vs 164, p<0.001) and increased inflammation.
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