Key result
Among elderly outpatients with dementia, 62.9% had at least one clinically important potential drug-drug interaction (risks C and D), including 8.7% with risk D interactions.
Cross-Sectional (n=97)
No
Elderly outpatients with dementia have a high prevalence (62.9%) of clinically important potential drug-drug interactions, highlighting the need for careful prescription monitoring.
Supports careful prescription review in elderly dementia outpatients; leaves open whether reducing interactions improves outcomes.
OBJECTIVE: To analyse the occurrence of potential high-risk drug-drug interactions in elderly individuals with dementia. METHODS: The sample was chosen from a geriatric outpatient clinic of the Multidisciplinary Center for the Elderly in the University Hospital of Brasília. This cross-sectional study included patients aged 60 or older with a diagnosis of dementia. The prescriptions were analyzed using the Lexi-Interact® database to identify possible potential drug-drug interactions. RESULTS: The study included 97 participants. Sixty-one patients (62.9%) had at least one clinically important potential drug-drug interactions (risks C and D). Of the 264 interactions identified, 23 (8.7%) were classified as risk D, 14 were pharmacodynamics and nine pharmacokinetic. CONCLUSION: The results of this study suggest an increased frequency in the occurrence of clinically significant potential drug-drug interactions in dementia patients. This reinforces the need for drug-drug interaction studies in specific populations.
No takes yet. Share an insight, caveat, or question.
Ferreira et al. (2015) conducted a cross-sectional in Dementia (n=97). Prescription drugs was evaluated on Occurrence of clinically important potential drug-drug interactions (risks C and D). Among elderly outpatients with dementia, 62.9% had at least one clinically important potential drug-drug interaction (risks C and D), including 8.7% with risk D interactions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: