What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: psychiatric disorders (n=94). Intervention: Polypharmacy and use of cardiovascular/respiratory drugs. Primary outcome: potential drug-drug interactions (DDIs).

What question did this study set out to answer?

To evaluate the prevalence of potential drug-drug interactions and polypharmacy in hospitalized older psychiatric patients and identify associated clinical risk factors.

September 11, 2017Journal of Psychiatric and Mental Health Nursing

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

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Key result

Polypharmacy and cardiovascular/respiratory drug use were significantly associated with a high prevalence of potential drug-drug interactions (up to 80.8%) in elderly psychiatric inpatients.

Population

94 institutionalized patients diagnosed with psychiatric disorders, aged >60 years, prescribed multiple…

Design

Cross-sectional

Follow-up

during hospitalization

Authors

ECEllen Carolina Dias CastilhoUniversidade de Ribeirão Preto ARAdriano Max Moreira ReisUniversidade Federal de Minas Gerais TBTatiana Longo BorgesCentro Universitário FEI

Discussion

Member takes

Implication

High potential DDI rates during elderly psychiatric hospitalization warrant vigilance; leaves open whether mitigation reduces clinical events.

Key Points

To evaluate the prevalence of potential drug-drug interactions and polypharmacy in hospitalized older psychiatric patients and identify associated clinical risk factors.
Conducted a retrospective cross-sectional study evaluating medical records of institutionalized patients aged >60 years with psychiatric disorders (n = 94) in a public hospital in Brazil.
Evaluated prescriptions for potential drug-drug interactions across three distinct intervals: hospital admission, midway through hospitalization, and the final prescription.
Assessed clinical and demographic factors associated with interaction occurrence using multivariable logistic regression analysis.
Potential drug-drug interaction prevalence rose across the hospital stay, occurring in 67.0% of patients at admission, 74.5% midway through hospitalization, and 80.8% on the final prescription.
Nervous system agents formed the majority of prescribed therapies, and analyses revealed a high frequency of serious and contraindicated interactions.
Patient age between 60 and 69 years, the total number of medications, and concurrent treatment with cardiovascular or respiratory drugs significantly increased interaction risk.

Study Design

Type

Cross-Sectional (n=94)

Multicenter

Structured PICO

Population

94 institutionalized elderly patients (aged >60 years) with psychiatric disorders and polypharmacy in a public hospital in Brazil.

Outcome

Potential drug-drug interactions and polypharmacysafety

In hospitalized elderly psychiatric patients, polypharmacy and the use of cardiovascular, respiratory, and nervous system drugs are associated with a high prevalence of potential drug-drug interactions.

Cite This Study

Castilho et al. (2017) conducted a cross-sectional in psychiatric disorders (n=94). Polypharmacy and use of cardiovascular/respiratory drugs was evaluated on potential drug-drug interactions (DDIs). Polypharmacy and cardiovascular/respiratory drug use were significantly associated with a high prevalence of potential drug-drug interactions (up to 80.8%) in elderly psychiatric inpatients.

synapsesocial.com/papers/6a98d9d3e739824d2c78bee1 https://doi.org/10.1111/jpm.12431

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Implication

High potential DDI rates during elderly psychiatric hospitalization warrant vigilance; leaves open whether mitigation reduces clinical events.

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider