Why the study?
Does long term alpha interferon treatment improve outcomes in haemophilia patients with chronic hepatitis C?
Does long term alpha interferon treatment improve outcomes in haemophilia patients with chronic hepatitis C?
HCV-RNA detection by PCR is more sensitive than ALT activity measurement in detecting relapse after interferon treatment in chronic hepatitis C.
May support long-term interferon in select haemophilia patients with HCV; leaves open efficacy confirmation and PCR-based monitoring in prospective trials.
This pilot study was designed to establish the effect of long term alpha interferon treatment in haemophilia patients with chronic hepatitis C. Overall, three of eight (37.5%) patients showed a complete response, three of eight (37.5%) a transient response, and two of eight (25.0%) no response. HCV-RNA detection by polymerase chain reaction was more sensitive in detecting relapse than alanine amino-transferase (ALT) activity measurement, suggesting that current interferon schedules based on the ALT response should be re-evaluated critically.
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Bresters et al. (1993) studied this question.
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