Key result
Antihypertensive medications provided modest reductions in blood pressure in children, including a 6.50 mmHg decrease in systolic blood pressure with candesartan, with no consistent dose-response.
Why the study?
Do antihypertensive medications reduce systolic or diastolic blood pressure in children with hypertension?
Population
3,454 children with hypertension pooled from 21 RCTs.
Comparison
Antihypertensive medications of various drug… vs Placebo, another antihypertensive medication, or…
Design
Systematic_review, Included randomised controlled trials (RCTs)
Follow-up
3 to 24 weeks (average 7 weeks)
Authors
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Supports short-term use of antihypertensives in hypertensive children; leaves long-term outcomes and end-organ effects open.
Systematic Review (n=3,454)
Do antihypertensive medications reduce systolic or diastolic blood pressure in children with hypertension?
Mean Difference: -6.5 (95% CI -9.44–-3.56)
Commonly prescribed antihypertensive medications have a modest blood pressure-lowering effect in children and appear safe in the short term, though evidence on long-term outcomes and end-organ damage is lacking.
Chaturvedi et al. (2014) conducted a systematic review in Hypertension in children (n=3,454). Antihypertensive medications vs. Placebo or another medication was evaluated on Systolic blood pressure (candesartan vs placebo example) (MD -6.50 mmHg, 95% CI -9.44 to -3.56). Antihypertensive medications provided modest reductions in blood pressure in children, including a 6.50 mmHg decrease in systolic blood pressure with candesartan, with no consistent dose-response.
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