Thyroid Gland Abnormalities in Patients with the Syndrome of Spotty Skin Pigmentation, Myxomas, Endocrine Overactivity, and Schwannomas (Carney Complex)
Population
53 patients from 12 families with Carney complex and 11 patients undergoing prospective screening.
Design
Case_series
Authors
Discussion
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Member takes
Implication
May support thyroid ultrasonography in Carney complex; leaves open prospective validation of screening.
Structured PICO
P
Population
53 patients from 12 families with Carney complex (retrospective review) and 11 patients (6 familial, 5 sporadic) undergoing prospective screening (5 adults mean age 33.2 years, 6 children mean age 13.8 years).
I
Intervention
Thyroid ultrasonography and biochemical examination
O
Outcome
Presence of thyroid gland abnormalitiessurrogate
Thyroid gland abnormalities, ranging from cystic changes to carcinoma, are a common, autosomally dominant inherited component of Carney complex, detectable by ultrasonography.
Cite This Study
Stratakis et al. (1997) studied this question.