Why the study?
Does DDDR pacing improve exercise capacity compared to DDDO pacing in a patient with high grade AV block?
Does DDDR pacing improve exercise capacity compared to DDDO pacing in a patient with high grade AV block?
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DDDR pacing can prevent 2:1 pacemaker block and improve exercise capacity in patients with high grade AV block and intact sinus node function.
A patient having high grade AV block with intact sinus node function is presented in whom DDDR pacing provided the benefit of preventing 2:1 pacemaker block in response to exercise-induced sinus tachycardia. In paired treadmill tests with the patient blinded as to pacing mode, she was able to exercise longer (7.5 vs 6.6 METS) when programmed in DDDR than in DDDO. This is attributable to circumvention of 2:1 pacemaker block which had resulted in abrupt onset of fatigue and SOB (shortness of breath) when the sinus rate exceeded the maximum tracking rate of 130/min. Outpatient ambulatory electrocardiographic monitoring confirmed this phenomenon during relatively strenuous activity. The theoretic advantages of dual chamber rate modulated pacing compared to the DDDO and VVIR modes are discussed.
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Hanich et al. (1989) studied this question.
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