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September 1, 1999Regional Anesthesia & Pain Medicine

Changes in heart rate variability in elderly patients undergoing major noncardiac surgery under spinal or general anesthesia

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Key result

Spinal anesthesia maintained a more stable sympathovagal balance (LF/HF ratio) during surgery compared to general anesthesia, though both resulted in a postoperative decrease in all HRV bands.

Why the study?

Does spinal anesthesia compared to general anesthesia improve heart rate variability stability in elderly patients with high risk of ischemic heart disease undergoing major noncardiac surgery?

Population

40 elderly patients with a high risk of ischemic heart disease undergoing major noncardiac surgery

Comparison

Spinal anesthesia vs General anesthesia

Design

RCT, randomly assigned

Follow-up

until the third postoperative day

Authors

MBMichael BacklundInstitute of GeneticsLTL. ToivonenTampere University HospitalMTM. TuominenUniversity of Turku

Discussion

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Implication

Spinal anesthesia may be favored intraoperatively for autonomic stability in high-risk elderly patients; extends RCT evidence on anesthesia-HRV effects while highlighting postoperative depression.

Study Design

Type

RCT (n=40)

Randomization

Randomly assigned

Structured PICO

Does spinal anesthesia compared to general anesthesia improve heart rate variability stability in elderly patients with high risk of ischemic heart disease undergoing major noncardiac surgery?

P
Population
40 elderly patients with a high risk of ischemic heart disease undergoing elective total hip arthroplasty or peripheral vascular surgery, monitored until the third postoperative day.
I
Intervention
Spinal anesthesia
C
Comparator
General anesthesia
O
Outcome
Changes in heart rate variability (HRV) frequency bands (VLF, LF, HF, LF/HF ratio) measured by Holter monitoringsurrogate

Spinal anesthesia maintains intraoperative sympathovagal balance better than general anesthesia in high-risk cardiac patients, though both techniques result in prolonged postoperative autonomic depression.

Cite This Study

Backlund et al. (1999) conducted an RCT in High risk of ischemic heart disease undergoing major noncardiac surgery (n=40). Spinal anesthesia vs. General anesthesia was evaluated on Changes in heart rate variability (HRV) frequency bands. Spinal anesthesia maintained a more stable sympathovagal balance (LF/HF ratio) during surgery compared to general anesthesia, though both resulted in a postoperative decrease in all HRV bands.

synapsesocial.com/papers/6a7317424ad168cfcf2c1359https://doi.org/10.1016/s1098-7339(99)90002-0

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Approximate Entropy of Heart Rate as a Correlate of Postoperative Ventricular Dysfunction1993 · 173 citations
  2. 2Impaired vagal heart rate control in coronary artery disease.1987 · 138 citations
  3. 3Association of Perioperative Myocardial Ischemia with Cardiac Morbidity and Mortality in Men Undergoing Noncardiac Surgery1990 · 1,021 citations
  4. 4Physiology of Spinal Anesthesia1959 · 119 citations
  5. 5Sympathovagal Effects of Spinal Anesthesia Assessed by Heart Rate Variability Analysis1995 · 74 citations