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February 1, 2006Hormone and Metabolic Research

Suppression of Transforming Growth Factor-β1Gene Expression by Danggui Buxue Tang, a Traditional Chinese Herbal Preparation, in Retarding the Progress of Renal Damage in Streptozotocin-induced Diabetic Rats

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Key result

No clinical data is available as the provided text only contains the editorial board information for the journal.

Why the study?

Does Danggui buxue tang (DBT) improve renal function and metabolic parameters in streptozotocin-induced diabetic rats?

Population

Streptozotocin-induced diabetic rats

Comparison

Danggui buxue tang (DBT) for 8 weeks vs Benazepril (ACE inhibitor) or untreated control

Design

Preclinical

Follow-up

8 weeks

Authors

YZY. W. ZhangDXDanling XieArmy Medical UniversityBXBo Xia

Discussion

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Implication

No clinical data available on DBT; leaves open any renal benefit in human diabetic nephropathy.

Structured PICO

Does Danggui buxue tang (DBT) improve renal function and metabolic parameters in streptozotocin-induced diabetic rats?

P
Population
Streptozotocin-induced diabetic rats
I
Intervention
Danggui buxue tang (DBT) for 8 weeks
C
Comparator
Benazepril (ACE inhibitor) or untreated control
O
Outcome
Renal alterations (renal weight/body weight ratio, urinary albumin, beta(2)-microglobulin, urinary albumin excretion rate, and creatinine clearance)surrogate

Danggui buxue tang may slow the progression of diabetic nephropathy in rats by suppressing TGF-beta1 mRNA expression, independent of the renin-angiotensin system.

Cite This Study

Zhang et al. (2006) studied this question. No clinical data is available as the provided text only contains the editorial board information for the journal.

synapsesocial.com/papers/6a731afb02f7f7ff1dacb790https://doi.org/10.1055/s-2006-925118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the Mechanisms of Danggui Buxue Tang in the Treatment of Renal Anemia Using Network Pharmacology and Molecular Docking2025 · 1 citations
  2. 2Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice2012 · 22 citations
  3. 3The Mechanistic Evaluation of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, by Network Pharmacology2025
  4. 4Senkyunolide a from danggui buxue decoction protects podocytes against diabetic nephropathy via the mir-223-3p/nlrp3 inflammasome axis2026
  5. 5Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: A Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica sinensis2009 · 23 citations