Key result
In Duchenne Muscular Dystrophy, LVEF <35% predicted significant Holter findings and led to medication changes in 40% of patients compared to ≤4% in those with LVEF ≥35% (P<0.001).
Why the study?
Does left ventricular ejection fraction predict significant Holter findings and change in clinical management in pediatric and adolescent patients with Duchenne Muscular Dystrophy?
Cohort (n=235)
Does left ventricular ejection fraction predict significant Holter findings and change in clinical management in pediatric and adolescent patients with Duchenne Muscular Dystrophy?
p-value: p=<0.001
Significant Holter findings and sudden cardiac events are rare in DMD patients with LVEF >35%, indicating that Holter monitoring is highest yield in those with severe cardiac dysfunction.
LVEF <35% may identify DMD patients warranting closer arrhythmia surveillance; leaves open prospective validation of screening thresholds.
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Villa et al. (2016) conducted a cohort in Duchenne Muscular Dystrophy (n=235). Left ventricular ejection fraction (LVEF) <35% vs. LVEF ≥35% was evaluated on Change in medication based on Holter findings (p=<0.001). In Duchenne Muscular Dystrophy, LVEF <35% predicted significant Holter findings and led to medication changes in 40% of patients compared to ≤4% in those with LVEF ≥35% (P<0.001).
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