Key result
Low shear stress from the outer wall of a bifurcation induced four times the levels of VCAM-1 mRNA after four hours compared with levels induced by wall shear stress from a straight arterial section.
Why the study?
Does exposure to disease-prone coronary wall shear stress profiles increase VCAM-1 expression in cultured endothelial cells compared to undisturbed flow?
Population
Cultured endothelial cells (ECs)
Comparison
Wall shear stress profiles from regions prone to… vs WSS profile from a straight section of vessel…
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Supports flow-mediated endothelial activation in atherosclerosis; leaves open translation to human plaque prevention strategies.
Does exposure to disease-prone coronary wall shear stress profiles increase VCAM-1 expression in cultured endothelial cells compared to undisturbed flow?
Physiological coronary wall shear stress profiles from disease-prone regions significantly upregulate VCAM-1 expression in endothelial cells, supporting the role of hemodynamics in plaque localization.
O’Keeffe et al. (2009) studied Atherosclerosis. Wall shear stress (WSS) profiles from disease-prone regions vs. WSS profile from a straight section of vessel with undisturbed flow and static controls was evaluated on Vascular cell adhesion molecule-1 (VCAM-1) expression. Low shear stress from the outer wall of a bifurcation induced four times the levels of VCAM-1 mRNA after four hours compared with levels induced by wall shear stress from a straight arterial section.
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