Key result
Infection by a DAF-using strain of echovirus 11 is dependent upon cholesterol and an intact cytoskeleton, indicating entry via lipid rafts, whereas a non-DAF-using mutant was unaffected.
DAF usage by EV11 enables the virus to associate with lipid rafts and enter cells through a novel cholesterol- and cytoskeleton-dependent route.
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No immediate clinical implications; leaves open whether lipid-raft targeting merits testing against DAF-using enteroviruses in humans.
Stuart et al. (2002) studied Echovirus 11 infection (in vitro). Endocytosis inhibitors (nystatin, chlorpromazine, nocodazole, cytochalasin D) vs. Untreated cells / non-DAF-using mutant (EV11-207R) was evaluated on Viral infection and entry. Infection by a DAF-using strain of echovirus 11 is dependent upon cholesterol and an intact cytoskeleton, indicating entry via lipid rafts, whereas a non-DAF-using mutant was unaffected.
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