Key result
Various methods, including trough blood pressure measurements, ambulatory monitoring, and the missed dose technique, can be used to evaluate the duration of action of once-daily antihypertensive drugs.
Discusses methods like trough measurement, ambulatory monitoring, and the missed dose technique to evaluate the duration of action of once-daily antihypertensive drugs.
These methods aid assessment of once-daily antihypertensive duration; leaves open standardization and outcome validation in trials.
There are several methods available to determine the duration of action of an antihypertensive drug. Traditional approaches involve measurements of blood pressure (BP) at the end of the dosing interval (trough). Ambulatory BP monitoring can be used to obtain additional information on the time course and magnitude of the decrease in BP over a standard dosing interval. Use of the 'missed dose' technique makes it possible to demonstrate persistent reductions in BP beyond 24 h for drugs given on a once-daily basis.
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Martin G. Myers (2003) conducted a review in Hypertension. Methods for evaluating duration of action of antihypertensive drugs was evaluated. Various methods, including trough blood pressure measurements, ambulatory monitoring, and the missed dose technique, can be used to evaluate the duration of action of once-daily antihypertensive drugs.
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