Key result
Reduced brainstem perfusion (Cushing's mechanism) is proposed as a common physiological link underlying high total peripheral resistance and essential hypertension in giraffes, rats, and humans.
Population
Physiologically hypertensive giraffes, spontaneously hypertensive rats, and humans with essential hypertension
Design
Review
Authors
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May implicate brainstem hypoperfusion in essential hypertension across species; hypothesis-generating and leaves open any therapeutic targeting.
Proposes a novel physiological framework ('Cushing's mechanism') where essential hypertension is driven by reduced cerebral blood flow to the brainstem, suggesting future treatments should target cerebral arterial resistance.
Paton et al. (2008) conducted a review in Essential hypertension. Reduced brainstem perfusion (Cushing's mechanism) was evaluated. Reduced brainstem perfusion (Cushing's mechanism) is proposed as a common physiological link underlying high total peripheral resistance and essential hypertension in giraffes, rats, and humans.
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