Why the study?
Do sulfonylureas (glibenclamide and glimepiride) inhibit I(HERG) K+ currents in neuroblastoma cells and guinea-pig ventricular myocytes?
Population
Neuroblastoma cells and guinea-pig ventricular myocytes
Design
Preclinical
Authors
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May raise concern for glibenclamide-related repolarization effects; leaves open clinical relevance in humans.
Do sulfonylureas (glibenclamide and glimepiride) inhibit I(HERG) K+ currents in neuroblastoma cells and guinea-pig ventricular myocytes?
Glibenclamide inhibits HERG potassium channels, suggesting a potential mechanism for sulfonylurea-induced QT prolongation and arrhythmias.
Rosati et al. (1998) studied this question.
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