Why the study?
Does glibenclamide reduce the D-type outward current in hippocampal CA3 neurons from Wistar rats?
Does glibenclamide reduce the D-type outward current in hippocampal CA3 neurons from Wistar rats?
Sulphonylureas like glibenclamide may not be as selective for ATP-sensitive K channels as generally believed, as they also depress the D-type outward current in hippocampal neurons.
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Glibenclamide may lack KATP selectivity in neurons; hypothesis-generating for sulfonylurea effects, should not change practice.
Crépel et al. (1992) studied this question.
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