Key result
Chronic kidney disease patients on dialysis had significantly lower heart rate variability (SDNN 95.4 vs 127.5; p=0.001) compared to healthy controls, with no difference between dialysis modalities.
Why the study?
Does dialysis modality affect heart rate variability in patients with chronic kidney disease compared to healthy controls?
Cross-Sectional (n=58)
Does dialysis modality affect heart rate variability in patients with chronic kidney disease compared to healthy controls?
Absolute Event Rate: 95.4% vs 127.5%
p-value: p=0.001
Patients with CKD on dialysis have reduced heart rate variability compared to healthy controls, regardless of whether they receive hemodialysis or peritoneal dialysis.
Indicates autonomic dysfunction in dialysis patients; leaves open prognostic value and modality effects.
OBJECTIVE: Patients with chronic kidney disease have a worse prognosis and carry a high risk of cardiovascular death and in particular sudden cardiac death. Reduced heart rate variability predicted an increased risk of mortality in non-dialysis chronic kidney disease and patients on chronic dialysis treatment. MATERIAL and METHODS: In this sectional study, we analysed heart rate variability of 28 patients with chronic kidney disease on dialysis therapy compared to a healthy control group. Heart rate variability was measured with 24-hour Holter electrocardiography. The results were compared to 30 healthy controls. RESULTS: The patients with chronic kidney disease on dialysis therapy had significantly lower heart rate variability compared to control subjects (for SDNN and pNN50; 95.4±31.5 vs. 127.5±38.8; p=0.001 and 8.3±6.1 vs. 16±9; p<0.001, respectively). There was no difference in terms of heart rate variability among hemodialysis and peritoneal dialysis modalities (for SDNN and PNN50, 90.7±32 vs. 102.5±30.8, p=0.32 and 8.6±6.3 vs. 7.8±6, p= 0.71, respectively). CONCLUSION: Reduced autonomic function may be one of the factors for cardiovascular events in patients with chronic kidney disease on dialysis therapy. There were no differences between hemodialysis and peritoneal dialysis.
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Ulu et al. (2017) conducted a cross-sectional in Chronic kidney disease on dialysis therapy (n=58). Chronic kidney disease on dialysis therapy vs. Healthy controls was evaluated on Heart rate variability (SDNN) (p=0.001). Chronic kidney disease patients on dialysis had significantly lower heart rate variability (SDNN 95.4 vs 127.5; p=0.001) compared to healthy controls, with no difference between dialysis modalities.
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