Key result
Chronic renal failure patients undergoing hemodialysis had significantly lower ejection fraction (52.3% vs 63.7%, p<0.001) and decreased heart rate variability compared to controls.
Why the study?
Is cardiac autonomic neuropathy associated with left ventricular function impairment and disease duration in patients undergoing chronic hemodialysis?
Case-Control (n=42)
Is cardiac autonomic neuropathy associated with left ventricular function impairment and disease duration in patients undergoing chronic hemodialysis?
In patients undergoing chronic hemodialysis, cardiac autonomic neuropathy is significantly correlated with the duration of dialysis and the degree of left ventricular systolic impairment.
Answers are grounded in this paper and cite their sources.
Supports autonomic neuropathy-LV impairment link in hemodialysis; leaves open causal role and need for prospective trials.
OBJECTIVE: Autonomic neuropathy and impairment of left ventricular functions (LVF) have been frequently encountered in chronic renal failure (CRF). The aim of the present study was to evaluate the relationship of cardiac autonomic modulation impairments, as assessed by means of heart rate variability (HRV), with clinical characteristics, and left ventricular function in the patients with CRF undergoing hemodialysis (HD). METHODS: Twenty control subjects (Group I) and 22 comparable by age and gender patients with CRF undergoing hemodialysis (Group II) were enrolled in the study. After routine clinical and biochemical evaluations, electrocardiography, and 2 Dimensional, M Mode echocardiography were performed in all participants. Frequency domain HRV analysis was studied by using Kardiosis System. The powers (P1 and P2) and the central frequencies (F1 and F2) of low and of high frequency spectral bands were recorded. RESULTS: End systolic (ESV) and end diastolic volumes (EDV) were significantly higher in Group II (59.3 +/- 21.1mL vs. 34.0 +/- 14.3 mL and 131.5 +/- 37.3 mL vs. 96.9 +/- 18.9 mL, p < 0.01, p < 0.05, respectively) when compared to those of Group I. Ejection fraction (EF) and fractional shortening (FS) were significantly lower in Group II than in control subjects (52.3 +/- 2.4% vs. 63.7 +/- 10.1% and 0.29 +/- 0.01 vs. 0.34 +/- 0.07, p < 0.001, p < 0.05, respectively). P and P2 were decreased in Group II than in Group I (136.2 +/- 173.9 m s2 vs. 911.0 +/- 685.5 and 96.5 +/- 149.6 vs. 499.7 +/- 679.5, p < 0.001, p < 0.01, respectively). Significant correlations were found between high frequency spectral power and dialysis duration (DD), ESV, EDV, EF, FS (r = 0.52 p < 0.01, r = 0.68 p < 0.001, r = 0.65 p < 0.002, r = 0.66 p < 0.02, and r = 0.69 p < 0.01). CONCLUSION: As a result, the dependence of cardiac autonomic neuropathy on the disease duration and degree of left ventricular function impairment was shown in the patients undergoing chronic hemodialysis.
No takes yet. Share an insight, caveat, or question.
Karayaylalı et al. (2003) conducted a case-control in Chronic renal failure (n=42). Chronic renal failure undergoing hemodialysis vs. Control subjects was evaluated on Ejection fraction (p=<0.001). Chronic renal failure patients undergoing hemodialysis had significantly lower ejection fraction (52.3% vs 63.7%, p<0.001) and decreased heart rate variability compared to controls.
Synapse has enriched 10 related papers. Consider them for comparative context: