Key result
Plasma volume in patients with compensated heart failure was similar to healthy controls (37.3 vs 40.2 mL/kg, P=0.092), but contracted with increasing use of diuretics (P=0.031).
Why the study?
Does diuretic treatment dose correlate with plasma volume and can NT-proBNP predict plasma volume status in patients with compensated systolic heart failure?
Population
18 patients with medically treated, compensated systolic heart failure and 27 healthy volunteers
Comparison
Furosemide (0 to 160 mg) vs Healthy volunteers
Design
Cross-sectional
Authors
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High-dose diuretics associate with contracted plasma volume in compensated HF; hypothesis-generating for NT-proBNP volume assessment and warrants prospective study.
Observational (n=45)
Does diuretic treatment dose correlate with plasma volume and can NT-proBNP predict plasma volume status in patients with compensated systolic heart failure?
Absolute Event Rate: 37.3% vs 40.2%
p-value: p=0.092
In compensated heart failure, high doses of loop diuretics are associated with subnormal plasma volume, which cannot be reliably estimated by single NT-proBNP measurements.
Bonfils et al. (2010) conducted an observational in Compensated Systolic Heart Failure (n=45). Diuretic treatment (furosemide) vs. Healthy volunteers was evaluated on Plasma volume (p=0.092). Plasma volume in patients with compensated heart failure was similar to healthy controls (37.3 vs 40.2 mL/kg, P=0.092), but contracted with increasing use of diuretics (P=0.031).
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