Key result
Blockade of RhoA/ROCK signaling by pharmacological inhibitors markedly attenuated stretch-induced FAK and ERK1/2 phosphorylation in neonatal rat ventricular myocytes.
RhoA/ROCK signaling is essential for stretch-induced FAK phosphorylation in cardiac myocytes, highlighting a mechanotransduction pathway linked to the actin cytoskeleton.
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May guide cardiac mechanotransduction research; leaves open relevance to human ventricular remodeling or therapy.
Torsoni et al. (2005) studied this question. RhoA/ROCK inhibitors (C3 exoenzyme or Y-27632) during cyclic stretch vs. Untreated stretched cells / nonstretched cells was evaluated on FAK and ERK1/2 phosphorylation. Blockade of RhoA/ROCK signaling by pharmacological inhibitors markedly attenuated stretch-induced FAK and ERK1/2 phosphorylation in neonatal rat ventricular myocytes.
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