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September 1, 1966CirculationOpen Access

Evaluation of the Left Ventricle in Patients with Mitral Stenosis

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Why the study?

Does supine leg exercise during cardiac catheterization reveal abnormal left ventricular hemodynamics and compliance in patients with mitral stenosis compared to controls?

Population

32 patients with mitral stenosis and 9 control patients with innocent functional heart murmurs or…

Comparison

Modified form of supine leg exercise during… vs Resting state and 9 control patients

Design

Case-control

Authors

HFHarvey FeigenbaumRCRichard W. CampbellCWCharles M. Wunsch

Discussion

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Overview

Exercise hemodynamics during catheterization reveal abnormal left ventricular compliance in a subset of patients with mitral stenosis, which may contribute to reduced cardiac output.

Structured PICO

Does supine leg exercise during cardiac catheterization reveal abnormal left ventricular hemodynamics and compliance in patients with mitral stenosis compared to controls?

P
Population
32 patients with mitral stenosis and 9 control patients with innocent functional heart murmurs or hemodynamically insignificant stenotic valvular lesions
I
Intervention
Modified form of supine leg exercise during simultaneous left and right heart catheterization
C
Comparator
Resting state (within-subject) and 9 control patients (between-subject)
O
Outcome
Left ventricular end-diastolic pressure (LVEDP) and Δv/Δp ratio (ratio of mitral valve flow or diastolic left ventricular volume change to the slope of the rise of left ventricular diastolic pressure)surrogate

Exercise hemodynamics during catheterization reveal abnormal left ventricular compliance in a subset of patients with mitral stenosis, which may contribute to reduced cardiac output.

Limitations

  • Difficulties and limitations associated with this type of study are discussed in the full text (specifics not detailed in abstract)

Cite This Study

Feigenbaum et al. (1966) studied this question.

synapsesocial.com/papers/6a7324e2ca0cfc242ec233a2https://doi.org/10.1161/01.cir.34.3.462
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