Key result
Post-pericardiocentesis ibuprofen resolves constrictive physiology within ~10 days in acute effusive-constrictive pericarditis.
Why the study?
Does anti-inflammatory therapy with ibuprofen resolve constrictive physiology and prevent chronic constriction in a patient with acute effusive-constrictive pericarditis?
Case Report (n=1)
No
Does anti-inflammatory therapy with ibuprofen resolve constrictive physiology and prevent chronic constriction in a patient with acute effusive-constrictive pericarditis?
Effusive-constrictive pericarditis can present in an acute, transient form that resolves with non-steroidal anti-inflammatory therapy, avoiding the need for surgical pericardiectomy.
May indicate rapid reversibility of acute effusive-constrictive pericarditis with ibuprofen; leaves open whether this avoids pericardiectomy in broader populations.
A 52-year-old female developed acute idiopathic pericarditis, which was complicated with tamponade. Constrictive physiology persisted after pericardiocentesis, and effusive-constrictive pericarditis (ECP) was diagnosed. Constrictive physiology improved in 10 days with anti-inflammatory therapy. This case was remarkable because it showed that ECP may present in an acute and reversible form. (Level of Difficulty: Beginner.)
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Hirata et al. (2019) conducted a case report in Acute transient effusive-constrictive pericarditis complicated with tamponade (n=1). Ibuprofen following urgent pericardiocentesis was evaluated on Resolution of constrictive physiology on echocardiography. Ibuprofen (400 mg three times daily) after pericardiocentesis resolved constrictive physiology within 10 days in a 52-year-old woman with acute effusive-constrictive pericarditis.
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