October 1, 1996Journal of Cardiovascular Pharmacology and Therapeutics

Controlling Paroxysmal Atrial Fibrillation by a Combination of Amiodarone and Flecainide: Description of a Case With 15-Year Follow-up

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Why the study?

Does a combination of amiodarone and flecainide prevent symptomatic arrhythmia recurrences in a patient with refractory paroxysmal atrial fibrillation?

Structured PICO

Does a combination of amiodarone and flecainide prevent symptomatic arrhythmia recurrences in a patient with refractory paroxysmal atrial fibrillation?

Population

77-year-old man with no known cardiac disease and paroxysmal atrial fibrillation for 35 years with disabling symptoms and poor exercise tolerance, refractory to conventional therapy (n=1).

Intervention

Combination therapy of amiodarone (gradually reduced to 200 mg/day) and flecainide (100 mg twice a day).

Outcome

Symptomatic arrhythmia recurrencespatient reported

A combination of amiodarone and flecainide successfully maintained sinus rhythm without significant toxicity over 8 years in a patient with refractory paroxysmal atrial fibrillation.

Limitations

Single case report
Efficacy and safety need to be addressed in controlled clinical trials

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support amiodarone-flecainide in refractory paroxysmal AF; hypothesis-generating and should not change practice.

Cite This Study

Altamirano et al. (1996) studied this question.

synapsesocial.com/papers/6a73250c7c93a8454ca0bb2a https://doi.org/10.1177/107424849600100409

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Controlling Paroxysmal Atrial Fibrillation by a Combination of Amiodarone and Flecainide: Description of a Case With 15-Year Follow-up

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Controlling Paroxysmal Atrial Fibrillation by a Combination of Amiodarone and Flecainide: Description of a Case With 15-Year Follow-up

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider