Why the study?
Does glucagon improve atrioventricular conduction and ventricular automaticity in a canine model?
Population
14 dogs, including 4 evaluated for ventricular automaticity via vagal stimulation and 3 with experimentally…
Comparison
Glucagon 50 µ/kg vs Baseline (before glucagon administration)
Design
Preclinical
Authors
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Glucagon may enhance AV conduction in this canine model; leaves open translation to human AV block therapy.
Does glucagon improve atrioventricular conduction and ventricular automaticity in a canine model?
Glucagon significantly improves A-V conduction without increasing ventricular automaticity in dogs, even in the presence of propranolol, suggesting potential utility for treating A-V block.
Steiner et al. (1969) studied this question.
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