Why the study?
Does glucagon improve cardiovascular hemodynamics in hypovolemic dogs with reduced coronary blood flow?
Does glucagon improve cardiovascular hemodynamics in hypovolemic dogs with reduced coronary blood flow?
Glucagon exerts inotropic, chronotropic, and peripheral vascular effects even in hypovolemic dogs with impaired myocardial metabolism and reduced coronary blood flow.
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Extends glucagon's hemodynamic effects to hypovolemic models with coronary compromise; leaves open translation to human shock.
Glucagon in a dose of 50 mug/kg body weight was studied for its cardiovascular effects in hypovolemic dogs in which coronary blood flow was reduced to an average 40% of its control value and cardiac depression was evident. Myocardial contractility, as judged mainly by dP/dt and acceleration of aortic blood flow, was brought to a normal level for a short time. Systemic and coronary vascular resistances were markedly reduced. These effects were similar in normovolemic dogs. The inotropic, chronotropic, and peripheral vascular effects of glucagon can be evoked also in hypovolemic dogs in which coronary blood flow is less than normal and myocardial metabolism is impaired.
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Pinardi et al. (1975) studied this question.
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