Key result
Hepatitis B virus infection was associated with lower right ventricular fractional area change compared to controls (33% vs. 52%, p=0.001) and higher systolic pulmonary artery pressure.
Why the study?
Does hepatitis B virus infection affect right and left ventricular systolic functions compared to healthy controls?
Case-Control (n=100)
Does hepatitis B virus infection affect right and left ventricular systolic functions compared to healthy controls?
Absolute Event Rate: 33% vs 52%
p-value: p=0.001
Hepatitis B virus infection may be associated with right ventricular systolic dysfunction and pulmonary hypertension.
HBV may impair RV function and elevate sPAP; hypothesis-generating, should not change practice without prospective validation.
BACKGROUND: In this study we examined right and left ventricular systolic functions in hepatitis B virus (HBV) patients. MATERIAL/METHODS: The study included 50 HBsAg-positive patients (mean age; 33±13 years) and 50 other persons (mean age; 28±11 years) as a control group. Transthoracic echocardiography was performed in all the participants. Right and left ventricle systolic parameters were compared between these 2 groups. RESULTS: In the group of the patients with HBsAg positivity, the right ventricular fractional area change (RV FAC), tricuspid annular plane excursion (TAPSE) and RV myocardial systolic velocity (St) values were lower than in the control group (33±11 vs. 52±13%, p=0.001; 14.6±1.1 vs. 22.2±2.4 mm, p<0.001; 8.6±1.2 vs. 15.8±2.3 cm/s, p<0,001, respectively); the right atrium (RA) and RV diameters were higher than in controls (5.1±1.2 vs. 3.7±0.5 cm, p<0.001; 4.9±0.8 vs. 3.4±0.5 cm p<0.001, respectively); and systolic pulmonary artery pressure was higher than in control (39.3±9.5 vs. 22±8.4 mmHg, p<0.001). CONCLUSIONS: The findings showed that HBV infection may be associated with right ventricular systolic dysfunction and pulmonary hypertension.
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Demir et al. (2012) conducted a case-control in Hepatitis B virus (HBV) infection (n=100). Hepatitis B virus (HBV) infection vs. Control group (other persons) was evaluated on Right ventricular fractional area change (RV FAC) (p=0.001). Hepatitis B virus infection was associated with lower right ventricular fractional area change compared to controls (33% vs. 52%, p=0.001) and higher systolic pulmonary artery pressure.
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