Key result
HCV infection linked to impaired LV diastolic function.
Why the study?
Does Hepatitis C Virus (HCV) infection affect left ventricular systolic and diastolic functions and P-wave dispersion compared to controls?
Case-Control (n=100)
Does Hepatitis C Virus (HCV) infection affect left ventricular systolic and diastolic functions and P-wave dispersion compared to controls?
Absolute Event Rate: 7.6% vs 6.8%
p-value: p=0.0001
HCV infection is associated with echocardiographic signs of left ventricular diastolic dysfunction and increased P-wave dispersion, suggesting a potential link to cardiac arrhythmias and cardiomyopathy.
Association with diastolic dysfunction supports cardiac evaluation in HCV; leaves open causal role and antiviral effects on function.
BACKGROUND: Hepatitis secondary to infection with the hepatitis C virus (HCV) is one of the most common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HCV infection have been recognized. Dilated and hypertrophic cardiomyopathy associated with HCV infection have been recently described in the literature; however, the effect of HCV infection on the left ventricular systolic and diastolic functions is unknown. Therefore, in this study we aimed to examine left ventricular systolic and diastolic functions in HCV patients. METHODS AND RESULTS: The study included 50 anti-HCV positive patients and 50 persons for control groups. We performed transthorasic echocardiography and P-wave analysis on all participants. We compared left ventricle diastolic parameters, left ventricle ejection fraction, and P-wave dispersion (Pd) between these two groups. In the group with anti-HCV positivity, the ratio of E/A was found to be lower (1.2 ± 0.7 and 1.37 ± 0.6, P = 0.003); the ratio of E/Em was found to be higher (7.6 ± 1.51 and 6.8 ± 1.72, P = 0.0001). Maximum P-wave duration (Pmax) and Pd were higher in the patient group (99.3 ± 8 and 82.4 ± 7.8, P = 0.004; 44.1 ± 0.9 and 25.3 ± 1.5, P = 0.001). No other statistically significant difference was found between the two groups with regard to the left ventricle systolic and diastolic parameters. CONCLUSION: Our findings show that HCV infection may be associated with left ventricular systolic and diastolic dysfunction and cardiac arrhythmias.
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Demir et al. (2011) conducted a case-control in Hepatitis C Virus (HCV) infection (n=100). Hepatitis C Virus (HCV) infection vs. Control group was evaluated on E/Em ratio (p=0.0001). HCV infection was associated with impaired left ventricular diastolic function, evidenced by a higher E/Em ratio (7.6 vs 6.8, P=0.0001) and lower E/A ratio (1.2 vs 1.37, P=0.003) compared to controls.
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