Key result
Hepatopulmonary syndrome in liver cirrhosis was associated with a 100% rate of right ventricular diastolic dysfunction, compared to 72.2% in cirrhosis without HPS and 10.5% in controls (P<0.05).
Why the study?
Does hepatopulmonary syndrome affect right ventricular diastolic function in patients with liver cirrhosis?
Cross-Sectional (n=84)
Does hepatopulmonary syndrome affect right ventricular diastolic function in patients with liver cirrhosis?
Right ventricular diastolic dysfunction is highly prevalent in chronic liver disease and is significantly more pronounced in the presence of hepatopulmonary syndrome.
Answers are grounded in this paper and cite their sources.
May warrant closer RV monitoring in cirrhosis with hepatopulmonary syndrome; leaves open causal mechanisms and outcome impact.
AIM: Liver functions are affected in the course of cardiac diseases, and similarly, liver diseases affect cardiac functions. Many studies in the literature have shown that left ventricular systolic and/or diastolic dysfunction may develop during chronic liver disease. However, there are limited studies investigating right ventricular functions during chronic liver diseases. METHODS: A total of 84 patients who had no systolic and/or diastolic dysfunction in the left ventricle (LV) were evaluated; 46 patients with liver cirrhosis; 10 (21.74%) cirrhotic patients with hepatopulmonary syndrome (HPS) (group 1), 36 (78.26) cirrhotic patients without HPS (group 2), and 38 healthy individuals were treated as control. RESULTS: Right ventricular diastolic dysfunction was determined in all patients of group 1 (100%), 26 of group 2 (72.22 %), and 4 of the controls (10.52%) (P<0.05). Tricuspid deceleration time (dt) was significantly different between the groups (P<0.05). In addition, right atrium (RA) diameters, right ventricle (RV) diameters, and RV wall thickness were significantly different between the groups (P<0.05). Pulmonary artery pressure (P<0.05) and pulmonary vascular resistance (P<0.05) were also seen to be higher in group 1 than those in group 2 and control group. CONCLUSIONS: Right ventricular diastolic dysfunction rate is high in chronic liver diseases. In the presence of HPS, right ventricular diastolic dysfunction is more remarkable in patients than those without HPS. Right ventricular diastolic dysfunction may result in dilatation and hypertrophy in the right heart.
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Karabulut et al. (2006) conducted a cross-sectional in Liver cirrhosis and hepatopulmonary syndrome (n=84). Hepatopulmonary syndrome (HPS) vs. Liver cirrhosis without HPS and healthy controls was evaluated on Right ventricular diastolic dysfunction (p=<0.05). Hepatopulmonary syndrome in liver cirrhosis was associated with a 100% rate of right ventricular diastolic dysfunction, compared to 72.2% in cirrhosis without HPS and 10.5% in controls (P<0.05).
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