A significant complication in vascular surgery is biomaterial infection. The aim of our study was to obtain prolonged antibacterial protection of vascular grafts, employing covalent immobilization of gentamicin and physical adhesion of ciprofloxacin to gelatin-sealed prostheses. The longest (34 days) antibacterial activity (against E. coli) was shown by the hybride biomaterial bounded covalently with gentamicin as well as ionically with ciprofloxacin. In addition, the covalent immobilization of gentamicin enables an antibacterial protection of biomaterial from bacterial adhesion.
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Miazga‐Karska et al. (2009) studied this question.
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