In the experiment on rats it was shown that a daily injection of omeprazole (14 mg/kg, i.p.) during 28 days evoked the increase of gastrin plasma level by 189.3% (p<0.05). As a result, gastric mucosal hypertrophy was developed. Therefore, we can see the rise of gastric acid output by 283.7% (p<0.01). In rats in 28 days of combined treatment of peroxisome proliferator-activated receptors ligand pioglitazone (30 mg/kg, i.p.) and omeprazole gastric acid output was diminished by 53.4% in comparison to rats after 28 days of isolated omeprazole injection. But pioglitazone did not influence augmentation of gastrin plasma level evoked by omeprazole. Thus, the compensatory effect of pioglitazone on gastric acid secretion may indicate retardation of mucosal hypertrophy process evoked by hypergastrinemia.
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Tsyryuk et al. (2009) studied this question.
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