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February 11, 2018Journal of Cardiovascular MedicineOpen Access

Second generation cryoballoon ablation resulted in similar 12-month freedom from atrial fibrillation compared to contact force radiofrequency ablation (78% vs 76%, p=0.804).

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Why the study?

Does second-generation cryoballoon ablation improve freedom from atrial fibrillation compared to contact force radiofrequency ablation in patients with paroxysmal atrial fibrillation?

Population

92 consecutive patients with paroxysmal atrial fibrillation scheduled for transcatheter ablation

Comparison

Second-generation cryoballoon ablation vs Contact force radiofrequency ablation

Design

Cohort

Follow-up

12 months

Key result

Second generation cryoballoon ablation resulted in similar 12-month freedom from atrial fibrillation compared to contact force radiofrequency ablation (78% vs 76%, p=0.804).

Authors

MMMario MattaMAMatteo AnselminoFFFederico Ferraris

Discussion

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Overview

Second-generation cryoballoon and contact force radiofrequency ablation demonstrate similar 12-month efficacy and safety for paroxysmal atrial fibrillation, though cryoablation initially requires longer fluoroscopy time.

Study Design

Type

Cohort (n=92)

Multicenter

Yes

Structured PICO

Does second-generation cryoballoon ablation improve freedom from atrial fibrillation compared to contact force radiofrequency ablation in patients with paroxysmal atrial fibrillation?

P
Population
92 patients with paroxysmal atrial fibrillation undergoing their first transcatheter ablation, matched 1:1 by propensity score and followed for a mean of 12 months.
I
Intervention
Second-generation cryoballoon ablation
C
Comparator
Contact force (last-generation) radiofrequency ablation
O
Outcome
Freedom from atrial fibrillation after 12 monthshard clinical

Main Result

Absolute Event Rate: 78% vs 76%

p-value: p=0.804

Second-generation cryoballoon and contact force radiofrequency ablation demonstrate similar 12-month efficacy and safety for paroxysmal atrial fibrillation, though cryoablation initially requires longer fluoroscopy time.

Limitations

  • Limited study size may bound the strength of the results, particularly for infrequent features like procedural complications.
  • Non-randomized design does not exclude the risk of bias in scheduling patients for each procedure.
  • Extensive use of mapping systems to reduce radiological exposure implies a slight prolongation in procedural duration and variable increase in procedural costs.

Cite This Study

Matta et al. (2018) conducted a cohort in Paroxysmal atrial fibrillation (n=92). Second generation cryoballoon ablation vs. Contact force radiofrequency ablation was evaluated on Freedom from atrial fibrillation at 12 months (p=0.804). Second generation cryoballoon ablation resulted in similar 12-month freedom from atrial fibrillation compared to contact force radiofrequency ablation (78% vs 76%, p=0.804).

synapsesocial.com/papers/6a733257b7c0b64c22c3f9f2https://doi.org/10.2459/jcm.0000000000000633
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