Population
179 quiescent 'diseased' human atrial fibers obtained from 86 patients undergoing corrective cardiac surgery.
Comparison
Perfusion with various ionic solutions and… vs Normal Tyrode's solution.
Design
Preclinical
Authors
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Does not support altering antiarrhythmic approaches in atrial disease; leaves open the therapeutic relevance of Na/K conductance modulation pending in vivo validation.
The low resting membrane potential in diseased human atrial fibers is driven by a combination of decreased potassium conductance and increased sodium conductance, with the electrogenic sodium pump providing a protective hyperpolarizing effect.
Imanishi et al. (1987) studied this question.
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