Key Points
- To assess regional left ventricular function and quantify coronary collateral circulation adaptation following coronary artery occlusion in baboons compared to dogs.
- Implanted micromanometers and ultrasonic crystals into ischemic, marginal, and control left ventricular regions in baboons 7–15 days prior to anterior descending coronary artery occlusion.
- Tracked regional dimensions and systolic shortening dynamically at one minute and over several weeks post-occlusion.
- Measured and compared coronary collateral index values in control baboons and at one month post-occlusion against normal and post-infarct dog controls.
- Coronary occlusion immediately provoked systolic bulging and wall thinning in ischemic segments at one minute, with persistent end-diastolic expansion over weeks and no significant recovery of systolic shortening in ischemic or marginal segments.
- Coronary collateral index in control baboons was 55 ± 25 (SE) compared to 560 ± 74 in normal dogs, reaching 543 ± 144 in baboons versus 6,685 ± 716 in dogs at one month post-occlusion, resulting in infarcts comprising 14.2 ± 2% of left ventricular mass.
Structured PICO
PPopulationSedated baboons and normal dogs (preclinical model)
IInterventionOcclusion of the anterior descending coronary artery
CComparatorControl segments within the same animal, control baboons, and normal dogs
OOutcomeRegional left ventricular dimensions (systolic shortening, end-diastolic lengths) and coronary collateral indexsurrogate
Baboons exhibit minimal coronary collateral development compared to dogs, which likely explains differences in regional functional responses and infarct characteristics following coronary occlusion.